Anna Paquin Takes her Twins Out in NYC

Keeping it low key on Halloween, Anna Paquin and her twins, Poppy and Charlie, ran a few errands in New York City on Thursday (October 31).

The "True Blood" beauty enjoyed some time with her adorable kiddos as they made their way around the busy city streets.

As previous reported by GossipCenter, Anna's anticipated superhero flick "X-Men: Day of Future Past" unleashed a full-length trailer for the all the fans to enjoy.

Starring alongside Miss Paquin are familiar X-Men favorites including Jennifer Lawrence, Halle Berry, Hugh Jackman, Mihael Fassbender, Patrick Stewart and Ian McKellen.

"X-Men: Days of Future Past" is slated to hit theaters May 23rd, 2014!

Source: http://celebrity-gossip.net/anna-paquin/anna-paquin-1075013
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Jewell: Congress must fight for more park funds

FILE - This Sept. 3, 2013 file photo shows Interior Secretary Sally Jewell speaking in Anchorage, Alaska. Jewell says Congress needs to do more than talk when it comes to national parks, forests and other public lands. In her first major address since taking office this spring, Jewell called on Congress to fight for parks and other public lands in the federal budget. (AP Photo/Dan Joling, File)

FILE - This Sept. 3, 2013 file photo shows Interior Secretary Sally Jewell speaking in Anchorage, Alaska. Jewell says Congress needs to do more than talk when it comes to national parks, forests and other public lands. In her first major address since taking office this spring, Jewell called on Congress to fight for parks and other public lands in the federal budget. (AP Photo/Dan Joling, File)

WASHINGTON (AP) — Interior Secretary Sally Jewell says Congress needs to do more than talk when it comes to national parks, forests and other public lands.

In her first major address since taking office this spring, Jewell called on Congress to push for full funding for parks and other public lands in the federal budget.

"The real test of whether you support conservation is not what you say in a press conference when the cameras are rolling, but whether you fight for it in the budget conference," Jewell said Thursday.

Jewell, the former head of outdoor retailer REI, took over in April as the nation's chief natural resources steward. Interior manages more than 500 million acres in national parks and other public lands — 20 percent of the nation's total lands. The department oversees development of about 20 percent of U.S energy supplies, as well as recreation and hunting and other services.

Still reeling from what she called an "absurd, wasteful" government shutdown, Jewell said lawmakers should consider what conservation legacy they will leave for the next 50 or 100 years.

"We owe it to future generations to act," she said, adding that "short-sighted funding and partisan gridlock" were unacceptable.

If Congress does not act to protect mountains, rivers and forests from development, President Barack Obama will use his executive authority to do so, Jewell said. Obama designated five new national monuments earlier this year and will not hesitate to protect historic or ecologically significant sites, she said.

"There's no question that if Congress doesn't act, we will act," Jewell said.

During the 16-day government shutdown, national parks became a political symbol as lawmakers bickered over who was to blame for closing the Grand Canyon and other national landmarks.

Republicans criticized the Obama administration for closing access to the open-air World War II Memorial on the National Mall after the government closed on Oct. 1. A crowd that included Republican lawmakers converged on the memorial at one point, pushing past barriers to protest the site's closure.

Jewell defended placement of barricades at the World War II Memorial and other sites, saying that all but a dozen National Park Service employees who work at the National Mall had been furloughed. The Park Service allowed veterans and their families to visit the memorial, she said.

Jewell said there was "absolutely no political motive" in the shutdown of the 401 national park units, adding that Park Service workers and others in the Interior Department followed federal law requiring that employees limit their actions to those that protect life and property.

"We did the best we could," she said.

Jewell said the Interior Department is working to strengthen landscape-level planning efforts to ensure balanced development on public lands. She announced a strategy aimed at ensuring that energy projects include steps to mitigate a range of environmental impacts, from endangered species to climate change. The policy will use science and technology to advance conservation while allowing development to continue, she said.

"We know it doesn't have to be an either-or," Jewell said. The department has set a goal of 20,000 megawatts of renewable energy on public lands by 2020. That's enough to power more than 5 million homes or businesses.

With about a third of Interior's 70,000 workers eligible to retire within five years, the department faces an urgent need for new generation of wildlife biologists, park rangers, scientists and other professionals, Jewell said.

"What happens when a generation who has little connection to our nation's public lands is suddenly in charge of taking care of them?" she asked.

Jewell laid out what she called ambitious goals to provide outdoor recreation opportunities for more than 10 million young people and 100,000 work and training opportunities in the next four years.

The department will work with businesses and non-profit organizations to raise up to $20 million in private funds to support those goals, Jewell said.

___

Follow Matthew Daly on Twitter: https://twitter.com/MatthewDalyWDC

Associated PressSource: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-10-31-Jewell-Conservation/id-170f2a09c1ff4c70a9715ca243627145
Category: notre dame football   nytimes  

Mick Jagger says he never hit on Katy Perry at 18

FILE - This July 28, 2013 file photo shows singer Katy Perry at the world premiere of "The Smurfs 2" in Los Angeles. Perry says though she’s “older and wiser,” she still plans to have fun on her new album. During an interview with an Australian radio show this week, the pop star said she sang backing vocals for Mick Jagger’s 2004 song, “Old Habits Die Hard.” Perry said she had dinner with the veteran rocker and that “he hit on me when I was 18.” In a statement Thursday, Oct. 31, a representative for Jagger says he “categorically denies that he has ever made a pass at Katy Perry.” (Photo by Jordan Strauss/Invision/AP, File)

NEW YORK (AP) — In her teenage dream? Mick Jagger says he never hit on Katy Perry when she was 18.

During an interview with an Australian radio show this week, the pop star said she sang backing vocals for Jagger's 2004 song "Old Habits Die Hard." Perry said she had dinner with the veteran rocker and that "he hit on me when I was 18."

In a statement Thursday, a representative for Jagger says he "categorically denies that he has ever made a pass at Katy Perry." The rep adds: "Perhaps she is confusing him with someone else."

Perry was one of the singers to make a guest appearance on the Rolling Stones' tour this year. The 29-year-old singer also said in the interview that the 70-year-old Jagger has been "very kind" to her.

• Arts & Entertainment
• Celebrities
• Mick Jagger
• Katy Perry

Source: http://news.yahoo.com/mick-jagger-says-never-hit-katy-perry-18-184315896.html
Related Topics: Jeff Soffer   james franco   Wojciech Braszczok   Merritt Wever   amc  

HIV antibody infusions show promise for treating SHIV-infected monkeys

PUBLIC RELEASE DATE:

31-Oct-2013

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Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

NIH-supported scientists advocate trying similar strategy in people

WHAT:

Two teams are reporting results from experiments in which they infused powerful anti-HIV antibodies into monkeys infected with an HIV-like virus, rapidly reducing the amount of virus, or viral load, to undetectable levels, where it remained for extended periods. One study was led by government scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the other was led by NIAID grantees at Beth Israel Deaconess Medical Center. Both teams worked with monkeys infected with simian human immunodeficiency virus, or SHIV, which can cause AIDS in monkeys. The researchers selected monoclonal antibodies that targeted two different sites on SHIV and gave the monkeys either one or two infusions of one or a combination of two or three of these antibodies. Then the scientists measured changes in the monkeys' viral load and their immune responses to the virus.

In the study led by NIAID grantees, the antibody infusions reduced SHIV viral load to an undetectable level in 16 of 18 monkeys within just 7 days and kept it there for a median of 56 days, when the infused antibodies were gone. While the two monkeys with the highest viral loads at the outset of the study never achieved undetectable viral loads, the three monkeys with the lowest viral loads at the outset maintained stable, undetectable viral loads long after the infused antibodies were gone. The antibody infusions appeared both to improve the monkeys' control of the virus and to reduce the presence of SHIV DNA in blood and tissues without generating SHIV resistance to the antibodies.

In the study led by NIAID scientists, infusion of a single antibody into 4 monkeys infected for 3 months quickly reduced SHIV viral load to undetectable levels for 4 to 7 days, but then virus reappeared and strains in two animals were antibody-resistant. Yet when two asymptomatic monkeys SHIV-infected for more than 3 years received an infusion of two antibodies, viral load fell to undetectable levels within 7 to 10 days and remained there for 18 to 36 days. A second infusion reduced viral load to undetectable levels for 4 to 28 days. When virus reappeared, strains in one monkey were antibody-resistant. Infusion of the same antibody pair into three monkeys SHIV-infected for more than 3 years and with AIDS symptoms provided modest or no benefit but did not generate resistance.

The studies' authors now propose testing antibody-based immunotherapy in HIV-infected people and exploring the potential role of antibody infusions in curing people of HIV.

###

ARTICLES:

DH Barouch et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature DOI: 10.1038/nature12744 (2013).

M Shingai et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viremia. Nature DOI: 10.1038/nature12746 (2013).

WHO:

NIAID Director Anthony S. Fauci, M.D., and Distinguished NIH Senior Investigator Malcolm A. Martin, M.D., are available for comment.

CONTACT:

To schedule interviews, please contact Laura S. Leifman, (301) 402-1663, laura.sivitz@nih.gov.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health

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PUBLIC RELEASE DATE:

31-Oct-2013

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Contact: Laura S. Leifman
laura.sivitz@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases

NIH-supported scientists advocate trying similar strategy in people

WHAT:

Two teams are reporting results from experiments in which they infused powerful anti-HIV antibodies into monkeys infected with an HIV-like virus, rapidly reducing the amount of virus, or viral load, to undetectable levels, where it remained for extended periods. One study was led by government scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the other was led by NIAID grantees at Beth Israel Deaconess Medical Center. Both teams worked with monkeys infected with simian human immunodeficiency virus, or SHIV, which can cause AIDS in monkeys. The researchers selected monoclonal antibodies that targeted two different sites on SHIV and gave the monkeys either one or two infusions of one or a combination of two or three of these antibodies. Then the scientists measured changes in the monkeys' viral load and their immune responses to the virus.

In the study led by NIAID grantees, the antibody infusions reduced SHIV viral load to an undetectable level in 16 of 18 monkeys within just 7 days and kept it there for a median of 56 days, when the infused antibodies were gone. While the two monkeys with the highest viral loads at the outset of the study never achieved undetectable viral loads, the three monkeys with the lowest viral loads at the outset maintained stable, undetectable viral loads long after the infused antibodies were gone. The antibody infusions appeared both to improve the monkeys' control of the virus and to reduce the presence of SHIV DNA in blood and tissues without generating SHIV resistance to the antibodies.

In the study led by NIAID scientists, infusion of a single antibody into 4 monkeys infected for 3 months quickly reduced SHIV viral load to undetectable levels for 4 to 7 days, but then virus reappeared and strains in two animals were antibody-resistant. Yet when two asymptomatic monkeys SHIV-infected for more than 3 years received an infusion of two antibodies, viral load fell to undetectable levels within 7 to 10 days and remained there for 18 to 36 days. A second infusion reduced viral load to undetectable levels for 4 to 28 days. When virus reappeared, strains in one monkey were antibody-resistant. Infusion of the same antibody pair into three monkeys SHIV-infected for more than 3 years and with AIDS symptoms provided modest or no benefit but did not generate resistance.

The studies' authors now propose testing antibody-based immunotherapy in HIV-infected people and exploring the potential role of antibody infusions in curing people of HIV.

###

ARTICLES:

DH Barouch et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature DOI: 10.1038/nature12744 (2013).

M Shingai et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viremia. Nature DOI: 10.1038/nature12746 (2013).

WHO:

NIAID Director Anthony S. Fauci, M.D., and Distinguished NIH Senior Investigator Malcolm A. Martin, M.D., are available for comment.

CONTACT:

To schedule interviews, please contact Laura S. Leifman, (301) 402-1663, laura.sivitz@nih.gov.

NIAID conducts and supports researchat NIH, throughout the United States, and worldwideto study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-10/nioa-hai103113.php
Category: Rebel Wilson   The Family   twin towers   Asap Rocky   msft  

Racism linked with gun ownership and opposition to gun control in white Americans

PUBLIC RELEASE DATE:

31-Oct-2013

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Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

A new study has found that higher levels of racism in white Americans is associated with having a gun in the home and greater opposition to gun control policies.

The research, published in PLoS One, was led by Dr Kerry O'Brien from The University of Manchester and Monash University and used data from a large representative sample of white US voters.

After accounting for numerous other factors such as income, education and political ideology, the researchers found that for each one point increase (on a scale from one to five) in symbolic racism there was a 50 percent increase in the odds of having a gun in the home and a 28 percent increase in support for policies allowing people to carry concealed guns.

Each one point increase in symbolic racism (a modern measure of anti-black racism) was also associated with a 27 percent increase in the odds of opposing bans on hand guns in the home. After accounting for those who already had a gun in the home, the odds were reduced to a non-significant 17 percent increase. However, the authors note that this reduction is unsurprising as opposition to bans on guns equates to self interest on behalf of those who already own a gun and do not wish to give it up. And racism was already strongly associated with having a gun in the home.

The research was stimulated by gun control debates in the US after mass shootings such as the Sandy Hook tragedy, and research showing that with all things being equal black Americans are more likely to be shot than whites. The most recent figures show that there are approximately 38,000 gun related deaths in the US each year. With other research suggesting that having a gun in the home is related to a 2.7 and 4.8 fold increase in the risk of a member of that home dying from homicide or suicide, respectively.

Dr O'Brien said: "Coming from countries with strong gun control policies, and a 30-fold lower rate of gun-related homicides, we found the arguments for opposing gun control counterintuitive and somewhat illogical. For example, US whites oppose gun control to a far greater extent than do blacks, but whites are actually more likely to kill themselves with their guns, than be killed by someone else. Why would you keep them? So we decided to examine what social and psychological factors predict gun ownership and opposition to gun control."

Conservatism, anti-government sentiment, party identification, being from a southern state, were also associated with opposition to gun controls, but the association between racism and the gun-related outcomes remained after accounting for these factors and other participant characteristics (age, education, income, gender).

Symbolic racism supplanted old-fashioned or overt/blatant racism which was associated with open support for race inequality and segregation under 'Jim Crow Laws', but it still captures the anti-black sentiment and traditional values that underpinned blatant racism. Symbolic racism has also been found to be related to stronger opposition to policies that may benefit blacks (e.g. welfare), and greater support for policies that seem to disadvantage blacks (e.g. longer prison sentences).

Study co-author Dr Dermot Lynott, from Lancaster University, said: "We were initially surprised that no one had studied this issue before; however, the US government cut research funding for gun-related research over decade and a half ago, so research in this area has been somewhat suppressed."

Dr O'Brien said: "According to a Pew Research Center report the majority of white Americans support stricter gun control, but the results of our study suggest that those who oppose gun reform tend to have a stronger racial bias, tend to be politically and ideologically conservative and from southern states, and have higher anti-government sentiment."

He added: "The study is a first step, but there needs to be more investment in empirical research around how racial bias may influence people's policy decisions, particularly those policies that impact on the health and wellbeing of US citizens."

###

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

PUBLIC RELEASE DATE:

31-Oct-2013

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]


Share

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

A new study has found that higher levels of racism in white Americans is associated with having a gun in the home and greater opposition to gun control policies.

The research, published in PLoS One, was led by Dr Kerry O'Brien from The University of Manchester and Monash University and used data from a large representative sample of white US voters.

After accounting for numerous other factors such as income, education and political ideology, the researchers found that for each one point increase (on a scale from one to five) in symbolic racism there was a 50 percent increase in the odds of having a gun in the home and a 28 percent increase in support for policies allowing people to carry concealed guns.

Each one point increase in symbolic racism (a modern measure of anti-black racism) was also associated with a 27 percent increase in the odds of opposing bans on hand guns in the home. After accounting for those who already had a gun in the home, the odds were reduced to a non-significant 17 percent increase. However, the authors note that this reduction is unsurprising as opposition to bans on guns equates to self interest on behalf of those who already own a gun and do not wish to give it up. And racism was already strongly associated with having a gun in the home.

The research was stimulated by gun control debates in the US after mass shootings such as the Sandy Hook tragedy, and research showing that with all things being equal black Americans are more likely to be shot than whites. The most recent figures show that there are approximately 38,000 gun related deaths in the US each year. With other research suggesting that having a gun in the home is related to a 2.7 and 4.8 fold increase in the risk of a member of that home dying from homicide or suicide, respectively.

Dr O'Brien said: "Coming from countries with strong gun control policies, and a 30-fold lower rate of gun-related homicides, we found the arguments for opposing gun control counterintuitive and somewhat illogical. For example, US whites oppose gun control to a far greater extent than do blacks, but whites are actually more likely to kill themselves with their guns, than be killed by someone else. Why would you keep them? So we decided to examine what social and psychological factors predict gun ownership and opposition to gun control."

Conservatism, anti-government sentiment, party identification, being from a southern state, were also associated with opposition to gun controls, but the association between racism and the gun-related outcomes remained after accounting for these factors and other participant characteristics (age, education, income, gender).

Symbolic racism supplanted old-fashioned or overt/blatant racism which was associated with open support for race inequality and segregation under 'Jim Crow Laws', but it still captures the anti-black sentiment and traditional values that underpinned blatant racism. Symbolic racism has also been found to be related to stronger opposition to policies that may benefit blacks (e.g. welfare), and greater support for policies that seem to disadvantage blacks (e.g. longer prison sentences).

Study co-author Dr Dermot Lynott, from Lancaster University, said: "We were initially surprised that no one had studied this issue before; however, the US government cut research funding for gun-related research over decade and a half ago, so research in this area has been somewhat suppressed."

Dr O'Brien said: "According to a Pew Research Center report the majority of white Americans support stricter gun control, but the results of our study suggest that those who oppose gun reform tend to have a stronger racial bias, tend to be politically and ideologically conservative and from southern states, and have higher anti-government sentiment."

He added: "The study is a first step, but there needs to be more investment in empirical research around how racial bias may influence people's policy decisions, particularly those policies that impact on the health and wellbeing of US citizens."

###

---

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Source: http://www.eurekalert.org/pub_releases/2013-10/uom-rlw103013.php
Related Topics: Kendrick Johnson   tony romo   Dylan Penn   elton john   Richard Sherman  

Results of the FREEDOM sub study reported at TCT 2013

PUBLIC RELEASE DATE:

31-Oct-2013

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Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation

Study examines the impact of insulin treatment status in diabetic patients with multivessel coronary artery disease

SAN FRANCISCO, CA October 31, 2013 According to a recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease (CAD), patients treated with insulin experienced more major adverse cardiovascular events after revascularization than those not treated with insulin.

The findings of a sub group analysis of the FREEDOM trial were presented today at the 25th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

The global prevalence of adult diabetes mellitus currently exceeds 6.4 percent (285 million) and is projected to increase to 7.7 percent (439 million) by 2030. In the United States, 26 percent of diabetics are treated with insulin; these patients comprise both patients with Type I diabetes as well as more advanced Type II diabetes. Insulin-treated patients are at increased risk for cardiovascular events after PCI and also have a higher risk of wound infection and mortality after coronary artery bypass surgery (CABG).

Results of the overall FREEDOM trial, which were first reported last year in the New England Journal of Medicine, found that coronary artery bypass grafting (CABG) reduces mortality and myocardial infarction rates compared to percutaneous coronary intervention (PCI), though it increases the chance of stroke. This FREEDOM sub group analysis examined the association of clinical outcomes after revascularization by insulin-treated diabetes mellitus (ITDM) status and the respective effect of CABG vs. PCI using first generation drug-eluting stents (PCI/DES). The primary endpoint was a composite of major adverse cardiac events including death, stroke and myocardial infarction analyzed using the logrank test and Cox regression to assess the interaction of treatment received and ITDM status.

A total of 1,850 diabetic patients with multi-vessel disease were randomized 1:1 to either CABG (894 patients) or PCI/DES (956 patients). Baseline and procedure characteristics were largely similar among the groups. A total of 602 patients (32.5 percent) had ITDM (PCI n=325, 34 percent; CABG n=277, 31 percent).

The estimated percentage of patients with a major adverse coronary event after five years was higher in the ITDM group compared to the non ITDM group (29 percent vs. 19 percent, respectively). Regardless of insulin treatment status, the estimated percentage of patients with major adverse coronary events after five years was higher among those that underwent PCI/DES (32 percent in the ITDM group and 25 percent in the non-ITDM group) compared to CABG (24 percent in the ITDM group and 16 percent in the non-ITDM group), although stroke rates were higher among CABG patients. In the ITDM group, the stroke rate was 7.5 for those who underwent CABG compared to 3.7 in those who had PCI/DES. In the non ITDM group, the stroke rate was 4.3 vs. 1.7 respectively.

"In patients with diabetes and multi-vessel coronary artery disease there are more major adverse cardiovascular events in patients treated with insulin than in those not treated with insulin," said study investigator George Dangas, MD, PhD. Dr. Dangas is Professor of Medicine at the Mount Sinai School of Medicine and Director of Cardiovascular Innovation at the Zena and Michael A. Wiener Cardiovascular Institute of the Mount Sinai Medical Center.

"However, the differences in clinical outcomes between CABG and PCI/DES were maintained regardless of the presence or absence of insulin treatment," Dr. Dangas said.

###

The FREEDOM trial was funded by NHLBI, NIH. Dr. Dangas reported no disclosures.

About CRF and TCT

The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in interventional cardiovascular medicine. CRF is the sponsor of the Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Celebrating its 25th anniversary this year, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. For more information, visit http://www.crf.org and http://www.tctconference.com.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

PUBLIC RELEASE DATE:

31-Oct-2013

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Contact: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation

Study examines the impact of insulin treatment status in diabetic patients with multivessel coronary artery disease

SAN FRANCISCO, CA October 31, 2013 According to a recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease (CAD), patients treated with insulin experienced more major adverse cardiovascular events after revascularization than those not treated with insulin.

The findings of a sub group analysis of the FREEDOM trial were presented today at the 25th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

The global prevalence of adult diabetes mellitus currently exceeds 6.4 percent (285 million) and is projected to increase to 7.7 percent (439 million) by 2030. In the United States, 26 percent of diabetics are treated with insulin; these patients comprise both patients with Type I diabetes as well as more advanced Type II diabetes. Insulin-treated patients are at increased risk for cardiovascular events after PCI and also have a higher risk of wound infection and mortality after coronary artery bypass surgery (CABG).

Results of the overall FREEDOM trial, which were first reported last year in the New England Journal of Medicine, found that coronary artery bypass grafting (CABG) reduces mortality and myocardial infarction rates compared to percutaneous coronary intervention (PCI), though it increases the chance of stroke. This FREEDOM sub group analysis examined the association of clinical outcomes after revascularization by insulin-treated diabetes mellitus (ITDM) status and the respective effect of CABG vs. PCI using first generation drug-eluting stents (PCI/DES). The primary endpoint was a composite of major adverse cardiac events including death, stroke and myocardial infarction analyzed using the logrank test and Cox regression to assess the interaction of treatment received and ITDM status.

A total of 1,850 diabetic patients with multi-vessel disease were randomized 1:1 to either CABG (894 patients) or PCI/DES (956 patients). Baseline and procedure characteristics were largely similar among the groups. A total of 602 patients (32.5 percent) had ITDM (PCI n=325, 34 percent; CABG n=277, 31 percent).

The estimated percentage of patients with a major adverse coronary event after five years was higher in the ITDM group compared to the non ITDM group (29 percent vs. 19 percent, respectively). Regardless of insulin treatment status, the estimated percentage of patients with major adverse coronary events after five years was higher among those that underwent PCI/DES (32 percent in the ITDM group and 25 percent in the non-ITDM group) compared to CABG (24 percent in the ITDM group and 16 percent in the non-ITDM group), although stroke rates were higher among CABG patients. In the ITDM group, the stroke rate was 7.5 for those who underwent CABG compared to 3.7 in those who had PCI/DES. In the non ITDM group, the stroke rate was 4.3 vs. 1.7 respectively.

"In patients with diabetes and multi-vessel coronary artery disease there are more major adverse cardiovascular events in patients treated with insulin than in those not treated with insulin," said study investigator George Dangas, MD, PhD. Dr. Dangas is Professor of Medicine at the Mount Sinai School of Medicine and Director of Cardiovascular Innovation at the Zena and Michael A. Wiener Cardiovascular Institute of the Mount Sinai Medical Center.

"However, the differences in clinical outcomes between CABG and PCI/DES were maintained regardless of the presence or absence of insulin treatment," Dr. Dangas said.

###

The FREEDOM trial was funded by NHLBI, NIH. Dr. Dangas reported no disclosures.

About CRF and TCT

The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in interventional cardiovascular medicine. CRF is the sponsor of the Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Celebrating its 25th anniversary this year, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. For more information, visit http://www.crf.org and http://www.tctconference.com.

---

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Source: http://www.eurekalert.org/pub_releases/2013-10/crf-rot_2103113.php
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Dylan's guitar from Newport to be auctioned in NYC

NEW YORK (AP) — The sunburst Fender Stratocaster that a young Bob Dylan played at the 1965 Newport Folk Festival when he famously went electric, perhaps the most historic instrument in rock 'n' roll, is coming up for auction, where it could bring as much as half a million dollars.

Though now viewed as changing American music forever, Dylan's three-song electric set at the Rhode Island festival that marked his move from acoustic folk to electric rock 'n' roll was met by boos from folk purists in the crowd who viewed him as a traitor. He returned for an acoustic encore with "It's All Over Now, Baby Blue."

The guitar is being offered for sale Dec. 6, Christie's told The Associated Press. Five lots of hand- and typewritten lyric fragments found inside the guitar case — early versions of some of Dylan's legendary songs — also are being sold. The lyrics have a pre-sale estimate ranging from $3,000 to $30,000.

With a classic sunburst finish and original flat-wound strings, the guitar has been in the possession of a New Jersey family for nearly 50 years. Dylan left it on a private plane piloted by the owner's late father, Vic Quinto, who worked for Dylan's manager.

His daughter, Dawn Peterson, of Morris County, N.J., has said her father asked the management company what to do with the guitar but nobody ever got back to him.

Last year, she took it to the PBS show "History Detectives" to try to have it authenticated. The program enlisted the expertise of Andy Babiuk, a consultant to the Rock and Roll Hall of Fame and owner of an upstate New York vintage instrument shop, and Jeff Gold, a Dylan memorabilia expert. Both men, who appeared on the episode, unequivocally declared the artifacts belonged to Dylan.

Babiuk took the instrument apart and also compared it to close-up color photos of the guitar taken at the 1965 festival.

"I was able to match the wood grain on the body of the guitar ... and the unique grain of the rosewood fingerboard. Wood grains are like fingerprints, no two are exactly alike," Babiuk said in an interview. "Based on the sum of the evidence, I was able to identify that this guitar was the one that Bob Dylan had played in Newport."

Dylan's attorney and his publicist did not respond to email and phone requests for comment. Dylan and Peterson, who declined to be interviewed, recently settled a legal dispute over the items.

The terms of the settlement were not disclosed but allowed Peterson to sell the guitar and lyrics, according to Rolling Stone, which wrote in July about Peterson's quest to authenticate the guitar.

"Representatives for Bob Dylan do not contest the sale of the guitar, and are aware of Christie's plan to bring it to auction," a statement issued through Christie's said.

Dylan has generally looked upon his instruments to convey his art, akin to a carpenter's hammer, Howard Kramer, curatorial director of the Rock and Roll Hall of Fame, said last year. "I don't think he's dwelled on a guitar he hasn't played for 47 years," he said. "If he cared about it, he would have done something about it."

Festival founder George Wein told the AP that when Dylan finished playing, Wein was backstage and told him to go back out and play an acoustic number because that's what people expected. Dylan said he didn't want to do it and said he couldn't because he only had the electric guitar. Wein called out for a loaner backstage and about 20 musicians raised their acoustic guitars to offer them.

The lyrics for sale include "In the Darkness of Your Room," an early draft of "Absolutely Sweet Marie" from Dylan's "Blonde on Blonde" album, and three songs from the record's 1965 recording session that were not released until the 1980s: "Medicine Sunday" (the draft is titled "Midnight Train"), "Jet Pilot" and "I Wanna Be Your Lover."

Dylan's "going electric changed the structure of folk music," the 88-year-old Wein said. "The minute Dylan went electric, all these young people said, 'Bobby's going electric, we're going electric, too.'"

___

Associated Press writer Michelle R. Smith in Providence, R.I., contributed to this report.

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Researcher: Nazi Gestapo chief died in Berlin

FILE - Undated b/w file picture of former German Gestapo head Heinrich Mueller. For decades there were alleged sightings of Mueller in Cuba, Argentina and elsewhere. But Johannes Tuchel, director of Berlin’s German Resistance Memorial Center, said Thursday Oct. 31, 2013 he’s uncovered evidence Mueller didn’t make it out of Berlin. He says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that Mueller died and was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in a Jewish cemetery destroyed by the Nazis. (AP-Photo,File)

FILE - Undated b/w file picture of former German Gestapo head Heinrich Mueller. For decades there were alleged sightings of Mueller in Cuba, Argentina and elsewhere. But Johannes Tuchel, director of Berlin’s German Resistance Memorial Center, said Thursday Oct. 31, 2013 he’s uncovered evidence Mueller didn’t make it out of Berlin. He says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that Mueller died and was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in a Jewish cemetery destroyed by the Nazis. (AP-Photo,File)

A sculpture by German artist Will Lammert is pictured at the entrance to a Jewish cemetery and memorial in Berlin, Germany, Thursday, Oct. 31, 2013. Johannes Tuchel, director of Berlin’s German Resistance Memorial Center says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that German Gestapo head Heinrich Mueller was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in this Jewish cemetery destroyed by the Nazis. (AP Photo/Michael Sohn)

A sculpture by German artist Will Lammert is pictured at the entrance to a Jewish cemetery and memorial in Berlin, Germany, Thursday, Oct. 31, 2013. Johannes Tuchel, director of Berlin’s German Resistance Memorial Center says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that German Gestapo head Heinrich Mueller was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in this Jewish cemetery destroyed by the Nazis. (AP Photo/Michael Sohn)

A star of David is attached on a wall at the entrance to a jewish cemetery and memorial in Berlin, Germany, Thursday, Oct. 31, 2013. Johannes Tuchel, director of Berlin’s German Resistance Memorial Center says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that German Gestapo head Heinrich Mueller was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in a Jewish cemetery destroyed by the Nazis. (AP Photo/Michael Sohn)

A star of David behind a sculpture by German artist Will Lammert is pictured at the entrance to a Jewish cemetery and memorial in Berlin, Germany, Thursday, Oct. 31, 2013. Johannes Tuchel, director of Berlin’s German Resistance Memorial Center says several documents, including a 1945 death certificate and a grave digger’s testimony to police in 1963, make it “clear-cut” to him that German Gestapo head Heinrich Mueller was buried near the Luftwaffe headquarters in the final days of the war. He says Mueller was later disinterred and buried with thousands others in a common grave in a Jewish cemetery destroyed by the Nazis. (AP Photo/Michael Sohn)

BERLIN (AP) — It was one of the great remaining mysteries surrounding the final days of World War II — what happened to Heinrich Mueller, the head of the Gestapo secret police and the highest-ranking Nazi never to have been captured or located.

But a leading German researcher said Thursday he has uncovered historical documents indicating Mueller never made it more than a few hundred meters (yards) from Hitler's bunker in downtown Berlin and was eventually buried in a common grave in a Jewish cemetery destroyed by the Nazis.

Though Mueller's body hasn't been found, Johannes Tuchel, the director of Berlin's German Resistance Memorial Center, said the evidence he uncovered is "clear-cut."

He said that, according to a death certificate he found, Mueller died in the final days of the war in 1945 near the Luftwaffe headquarters.

Tuchel said other evidence shows that about three months after the end of the war Mueller's body was found by a work crew cleaning up corpses and buried along with about 3,000 others in a communal grave on the site of a Jewish cemetery that the SS had destroyed in 1943.

The documents show "with near certainty" that Mueller was buried in August 1945 in the garden of the Luftwaffe headquarters, then brought to the Jewish cemetery on Grosse Hamburger Strasse, said Tuchel, whose story was first reported by Bild newspaper.

Mueller, who was an SS Gruppenfuehrer — roughly equivalent to a major general — was sought for decades after the war by investigators around the world, including Israel's Mossad, the U.S. Office of Special Investigations, and the Simon Wiesenthal Center.

Tuchel said he had no explanation for why they hadn't come up with the same information. "That is a part of the puzzle I can't answer," he said.

The Simon Wiesenthal Center's top Nazi hunter, Efraim Zuroff, sounded a note of caution, saying only DNA evidence could prove Mueller was buried in Berlin.

"The Nazis who wanted to escape very often took measures to create false documents faking their death," he said in a telephone interview from London. "I would be very wary of reports like that without forensic evidence."

He cited the case of Aribert Heim, a Mauthausen concentration camp doctor who allegedly died in Cairo in 1992.

"Heim was buried, according to his son, in a mass grave for poor people in Cairo, and it's a perfect story because it's impossible to verify," Zuroff said.

It's not yet known whether any efforts will be made to find Mueller's bones in Berlin.

According to the Berlin Jewish Community's website, the cemetery included the grave of philosopher Moses Mendelssohn and was destroyed by the SS in 1943, when they built trenches through the area. At war's end, it was used to bury bombing victims and other war casualties that littered the German capital.

Tuchel came across the documents when researching an incident in which Mueller ordered the execution of 18 resistance members at the end of the war. In addition to a December 1945 death certificate for Mueller, Tuchel said he has evidence that the identity papers and medals were later turned over to military authorities to return to his family.

And in 1963 — when authorities were looking into a rumor that Mueller had been buried in West Berlin's Neukoelln district — a gravedigger told police in testimony Tuchel found that he had buried Mueller in the former Jewish cemetery, and had matched his identity papers to the face of the body.

Tuchel said the man did not give any indication as to Mueller's cause of death.

According to an article in the Holocaust and Genocide Studies journal in 2001, the gravedigger's story was known but could never be checked out because the graves were on the other side of the Berlin Wall.

Though there were persistent alleged sightings of Mueller in the decades after the war, including in Czechoslovakia, Cuba and Argentina, experts have always maintained that he most likely died in Berlin at the war's end.

That was the fate of Hitler's private secretary Martin Bormann, who was thought to have escaped the capital until his bones were unearthed during construction in 1972 in downtown Berlin. DNA tests in 1998 confirmed they were his.

Zuroff said that, if the information on Mueller does turn out to be true, it would be a "comforting thought" that Mueller — who attended the notorious 1942 Wannsee Conference in which plans were coordinated for the genocide of the European Jews — didn't escape.

"This is the biggest fish that got away," Zuroff said.

Still, if his final resting place is a Jewish cemetery, Zuroff said it would be "absolutely horrifying."

"It's the last place on earth where he should be buried," said Zuroff. "If this is ever verified, they'd better move very quickly to make sure it doesn't become a shrine for neo-Nazis."

___

AP Investigative Researcher Randy Herschaft contributed to this report from New York

Associated PressSource: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-10-31-Germany-Gestapo%20Head/id-f754b4cc1926456596215ec5f28bc054
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UK hacking prosecutor: Brooks, Coulson had affair

Andy Coulson arrives at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

Andy Coulson arrives at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

Rebekah Brooks and her husband Charlie Brooks arrive at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

Former News of The World news editor Ian Edmondson arrives at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

Former Royal Editor Clive Goodman arrives at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

Andy Coulson arrives at The Old Bailey law court in London, Thursday, Oct. 31, 2013. Former News of the World national newspaper editors Rebekah Brooks and Andy Coulson went on trial Monday, along with several others, on charges relating to the hacking of phones and bribing officials while they were employed at the now closed tabloid paper. (AP Photo/Kirsty Wigglesworth)

LONDON (AP) — In a blockbuster declaration at Britain's phone hacking trial, a prosecutor said two of Rupert Murdoch's former senior tabloid executives — Rebekah Brooks and Andy Coulson, later a top aide to Prime Minister David Cameron — had an affair lasting at least six years.

Prosecutor Andrew Edis made the disclosure Thursday during Coulson's and Brooks' trial on phone hacking and other charges, the first major criminal case to go to court in the hacking saga that has shaken Britain's political, judicial and media elite.

Brooks, Coulson and six other people are now on trial, including Brooks' current husband Charles. All deny the various charges against them, which range from phone hacking to bribing officials for scoops to obstructing police investigations.

Edis said the relationship between Brooks and Coulson was relevant to the hacking case because it showed they trusted one another and shared intimate information.

"Throughout the relevant period, what Mr. Coulson knew Mrs. Brooks knew, and what Mrs. Brooks knew Mr. Coulson knew," Edis said.

Edis said the affair began in 1998 and lasted about six years. If his timeline is correct, the affair ended before Coulson became Cameron's top communications director, which began after Cameron's election in 2010. Coulson started working for Cameron in 2007, when Cameron became leader of Britain's Conservative opposition party.

The affair covered the period when Brooks was the top editor of Murdoch's News of the World tabloid and Coulson was her deputy. Brooks edited the paper from 2000 to 2003, then went on to edit its sister paper, The Sun, and later became the chief executive of Murdoch's British newspaper division. Coulson edited the News of the World from 2003 to 2007.

The affair covered the crucial period in 2002 when the News of the World hacked the phone of murdered teenager Milly Dowler. Brooks has long denied knowing about that hacking. When the Dowler hacking case became public in 2011, the outrage in Britain was so great that Murdoch shut down the 168-year-old paper.

Edis said a February 2004 letter from Brooks showed there was "absolute confidence between the two of them in relation to all the problems at their work." He said the letter appeared to have been written by Brooks in response to Coulson's attempt to end the relationship.

"You are my very best friend. I tell you everything. I confide in you, I seek your advice," Brooks wrote, according to Edis. "Without our relationship in my life I am really not sure I will cope."

Edis said the affair was uncovered when police searched a computer found at Brooks' home in 2011 as part of the hacking investigation.

It's not clear whether the letter was ever sent.

Brooks married soap-opera star Ross Kemp in 2002. They later divorced and she married horse trainer Charles Brooks in 2009.

In his opening arguments Thursday, Edis said News of the World journalists, with consent from the tabloid's top editors, colluded to hack the phones of politicians, royalty, celebrities and even rival reporters in a "frenzy" to get scoops.

He said the "dog-eat-dog" environment led to routine lawbreaking that was sanctioned by those in charge of the Murdoch-owned tabloid: editors Rebekah Brooks and Coulson.

Jurors were shown email exchanges involving private investigator Glenn Mulcaire and News of the World news editor Ian Edmondson — one of the defendants — detailing the 2006 hacking of former government minister Tessa Jowell, royal family member Frederick Windsor and one-time Deputy Prime Minister John Prescott, who was the subject of a major kiss-and-tell story from a mistress.

Mulcaire also hacked the phones of two journalists at the rival Mail on Sunday tabloid who were working on their own story about the Prescott affair, the prosecutor said.

"In the frenzy to get the huge story ... that's what you do," Edis said.

Edis also played a recording of Mulcaire "blagging" — seeking information about a voicemail password from a service provider using a false name. He said Mulcaire — an "accomplished" blagger and hacker — made the recording himself, and also recorded some of the voicemails he hacked.

The prosecutor said the emails, the recordings and pages from Mulcaire's notebooks provided "very clear evidence" of hacking so widespread that senior editors must have known about it.

Edis said Mulcaire was paid almost 100,000 pounds a year under a contract that started in 2001 and ended when he was arrested in 2006 for hacking the phones of royal aides. He and the tabloid's royal editor Clive Goodman were briefly jailed and for years, Murdoch's media company maintained that hacking had been limited only to that pair.

That claim was demolished when the Dowler case became public in 2011. Murdoch's company has since paid millions in compensation to scores of people whose phones were hacked.

Rebekah Brooks, Coulson, Edmondson and former managing editor Stuart Kuttner all deny charges of phone hacking. The trial is expected to last roughly six months.

Mulcaire has pleaded guilty, along with three former News of the World news editors.

Edis said there are few records of what Mulcaire was paid to do by the newspaper, but that senior editors must have known of his illicit activity.

"The question is, did nobody ever ask, 'What are we paying this chap for?'" he said. "Somebody must have decided that what he was doing was worth an awful lot of money. Who was that?"

He said Rebekah Brooks, who edited the News of the World when Mulcaire was put on retainer "was actively involved in financial management" and sent editors stern emails about keeping costs down.

Under Coulson, who succeeded her as editor, Mulcaire's fee was increased to 2,019 pounds a week.

Edis said there was no evidence that Mulcaire's fees were ever questioned.

"You would question it — unless you knew all about it," Edis said.

___

Jill Lawless can be reached at http://Twitter.com/JillLawless

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Red Sox win 6-1, 1st WS title at home since 1918

Boston Red Sox manager John Farrell holds up the championship trophy after Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox beat the St. Louis Cardinals 6-1 to win the series. (AP Photo/Chris Carlson)

Boston Red Sox manager John Farrell holds up the championship trophy after Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox beat the St. Louis Cardinals 6-1 to win the series. (AP Photo/Chris Carlson)

Boston Red Sox David Ortiz, left, waves with his son Kaz after being named the game MVP by Commissioner of Major League Baseball Bud Selig after Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Matt Slocum)

Boston Red Sox's David Ortiz lifts Koji Uehara after Game 6 of baseball's World Series against the St. Louis Cardinals Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Matt Slocum)

Boston Red Sox relief pitcher Koji Uehara, left, holds the championship trophy with teammate Junichi Tazawa after defeating the St. Louis Cardinals in Game 6 of baseball's World Series, Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Elise Amendola)

Boston Red Sox relief pitcher Koji Uehara, left, holds the championship trophy with teammate Junichi Tazawa after defeating the St. Louis Cardinals in Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Elise Amendola)

BOSTON (AP) — More than an hour after the final out, players lingered on the field and fans stood by their seats, cheering, singing and applauding.

A celebration nearly a century in the making was unfolding at the old ballpark, a long-awaited moment generations of New Englanders had never been able to witness.

Turmoil to triumph. Worst to first. A clincher at Fenway Park.

David Ortiz and the Boston Red Sox, baseball's bearded wonders, capped their remarkable turnaround by beating the St. Louis Cardinals 6-1 in Game 6 on Wednesday night to win their third World Series championship in 10 seasons.

When it was over, Ortiz took a microphone on the field and addressed the city, just as he did a week after the marathon bombings last April.

"This is for you, Boston. You guys deserve it," the Series MVP said. "We've been through a lot this year and this is for all of you and all those families who struggled."

And the Red Sox didn't even have to fly the trophy home. For the first time since Babe Ruth's team back in 1918, Boston won the title at Fenway. The 101-year-old stadium, oldest in the majors, was jammed with 38,447 singing, shouting fans anticipating a party that had been building for more than nine decades.

"Maybe they won't have to go another 95 years," said John Farrell, a champion in his first season as Boston's manager.

Shane Victorino, symbolic of these resilient Sox, returned from a stiff back and got Boston rolling with a three-run double off the Green Monster against rookie sensation Michael Wacha. Pumped with emotion, Victorino pounded his chest with both fists three times.

John Lackey became the first pitcher to start and win a Series clincher for two different teams, allowing one run over 6 2-3 innings 11 years after his Game 7 victory as an Angels rookie in 2002.

With fans roaring on every pitch and cameras flashing, Koji Uehara struck out Matt Carpenter for the final out. The Japanese pitcher jumped into the arms of catcher David Ross while Red Sox players rushed from the dugout and bullpen as the Boston theme "Dirty Water" played on the public-address system.

There wasn't the "Cowboy Up!" comeback charm of "The Idiots" from 2004, who swept St. Louis to end an 86-year title drought. There wasn't that cool efficiency of the 2007 team that swept Colorado.

This time, they were Boston Strong — playing for a city shaken by tragedy.

"I don't think we put Boston on our back. I think we jumped on their back," Jonny Gomes said. "They wouldn't let us quit."

After a late-season collapse in 2011, the embarrassing revelations of a fried chicken-and-beer clubhouse culture that contributed to the ouster of manager Terry Francona, and the daily tumult of Bobby Valentine's one-year flop, these Red Sox grew on fans.

Just like the long whiskers on the players' faces, starting with Gomes' scruffy spring training beard.

"As soon as we went to Fort Myers, the movie's already been written," Gomes said. "All we had to do was press play, and this is what happened."

The only player remaining from the 2004 champs, Ortiz had himself a Ruthian World Series. He batted .688 (11 for 16) with two homers, six RBIs and eight walks — including four in the finale — for a .760 on-base percentage in 25 plate appearances, the second-highest in Series history.

"We have a lot of players with heart. We probably don't have the talent that we had in '07 and '04, but we have guys that are capable (of staying) focused and do the little things," Ortiz said.

Even slumping Stephen Drew delivered a big hit in Game 6, sending Wacha's first pitch of the fourth into the right-center bullpen for a 4-0 lead. By the time the inning was over, RBI singles by Mike Napoli and Victorino had made it 6-0, and the Red Sox were on their way.

"Hey, I missed two games. It's time to shine," Victorino said.

All over New England, from Connecticut's Housatonic River up to the Aroostook in Maine, Boston's eighth championship can be remembered for the beard-yanking bonding.

Fans bid up the average ticket price to over $1,000 on the resale market and some prime locations went for more than $10,000 each. Nearly all the Red Sox rooters stood in place for 30 minutes after the final out to view the presentation of the trophy and MVP award. A few thousand remained when a beaming Ortiz came back on the field with his son 75 minutes after the final out.

"It's so electric in here," Napoli said.

The win capped an emotional season for the Red Sox, one heavy with the memory of the events that unfolded on Patriots Day, when three people were killed and more than 260 wounded in bombing attacks at the Boston Marathon. The Red Sox wore "Boston Strong" logos on their left sleeves, erected a large emblem on the Green Monster and moved the logo into the center-field grass as a constant reminder.

"It's hard for me to put sports over a tragedy like that," Lackey said, "but hopefully people that were affected by it can forget about it for a few hours at least."

Red, white and blue fireworks fired over the ballpark as Commissioner Bud Selig presented the World Series trophy to Red Sox owners John Henry, Tom Werner and Larry Lucchino, leaving a haze over the field.

"When the fireworks went off at the presentation of the trophy out there, when the ballpark was filled with smoke, it was completely surreal," Farrell said. "To be in this position, given where we've come from, reflecting back a year ago at this time, there's been a lot that's happened in 13 months."

Among the players blamed for the indifferent culture at the end of the Francona years, Lackey took the mound two days shy of the second anniversary of his elbow surgery and got his first Series win since the 2002 clincher. He pitched shutout ball until Carlos Beltran's RBI single in the seventh.

St. Louis had been seeking its second title in three seasons, but the Cardinals sputtered after arriving in Boston late Tuesday following a seven-hour flight delay caused by mechanical problems. Symbolic of the team's struggles, reliever Trevor Rosenthal tripped while throwing a pitch to Ortiz in the eighth, balking Dustin Pedroia to second.

"They were some frustrated guys in there, but overall you can't ask us to go about any better than how our guys did," Cardinals manager Mike Matheny said. "Not too many people expected us to do what we did."

Boston was a 30-1 underdog to win the World Series last winter, but joined the 1991 Minnesota Twins as the only teams to win titles one season after finishing in last place. Now, the Red Sox will raise another championship flag before their home opener next season April 4 against Milwaukee.

Gomes was looking forward to Saturday's parade.

"It's time," he said, "to queue the duck boats."

NOTES: Boston also won the Series at Fenway Park in 1912. The Red Sox won the first World Series in 1903 at the Huntington Avenue Grounds and in 1916 at Braves Field. ... Ortiz's Game 5 bat is going to the Hall of Fame along with Uehara's Series spikes, Ross' Series jacket and Farrell's Game 6 jacket. Gomes' Game 4 home-run bat arrived in Cooperstown, N.Y., on Wednesday.

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